Bioinformatics and the politics of innovation in the life sciences: Science and the state in the United Kingdom, China, and India

The governments of China, India, and the United Kingdom are unanimous in their belief that bioinformatics should supply the link between basic life sciences research and its translation into health benefits for the population and the economy. Yet at the same time, as ambitious states vying for position in the future global bioeconomy they differ considerably in the strategies adopted in pursuit of this goal. At the heart of these differences lies the interaction between epistemic change within the scientific community itself and the apparatus of the state. Drawing on desk-based research and thirty-two interviews with scientists and policy makers in the three countries, this article analyzes the politics that shape this interaction. From this analysis emerges an understanding of the variable capacities of different kinds of states and political systems to work with science in harnessing the potential of new epistemic territories in global life sciences innovation

Stealth seeds: Bioproperty, biosafety, biopolitics

Transgenic seeds in both India (Bt cotton) and Brazil (glyphosate-resistant soybeans) spread widely and rapidly through farming communities outside the reach of biosafety or bioproperty institutions. Stealth transgenics are saved, cross-bred, repackaged, sold, exchanged and planted in an anarchic agrarian capitalism that defies surveillance and control of firms and states. The outcome is more pro-poor than alternative modes of diffusion, but undermines a growing consensus in the international development community on appropriate bio-safety and intellectual property institutions for biotechnology. Second, stealth procurement of biotechnology divides nominally pro-poor political coalitions, driven by a great ideational divide on uncertainties and risks of transgenics. The ability of seeds to move underground through stealth strategies of farmers undermines widely-assumed bio-safety-regime capability. Likewise, property in biotechnology appears less monopolistic and powerful, more relational and contingent. Stealth practices of farmers in pursuit of transgenics contrary to wishes of firms, states and many NGOs suggest a different model of the farmer than that often encountered in both developmentalist and anti-'GMO' discourse: more active, creative and autonomous, less hapless and supine. Resultant incapacity of social institutions to secure interests of firms and states in biotechnology renders more likely eventual development of controls from genetic engineering�-�the 'terminator technology' of political dramaturgy.

Reflexive Interdisciplinary Research: The Making of a Research Programme on the Rural Economy and Land Use

This paper provides an account of the origins and formation of the UK Research Councils' Rural Economy and Land Use (RELU) programme and its approach to promoting interdisciplinary working between social and natural scientists. The programme is set in the context of broader developments in science policy, including a policy discourse centred upon sustainable development and the knowledge economy and associated demands for greater accountability in science. Interdisciplinarity promises research that will be more relevant and responsive to public needs and concerns. In describing the provenance of the RELU programme, therefore, the paper seeks to lay out the different stages in its initiation and design to show how, to varying degrees, these were open to external scrutiny and influence. The process of developing the programme illustrates that it is not straightforward to make research agendas and funding more transparent and accountable. It also provides insights into the challenges that interdisciplinarity and accountability present to established science institutions. Copyright 2006 Blackwell Publishing Ltd.

Genomic data from the potato

Available here is the genome of the potato (Solanum tuberosum L.), the first genome sequenced from the asterid clade. Potato is a member of the Solanaceae, a plant family that includes many other economically important species, such as tomato, petunia, eggplant, tobacco, and pepper. As the potato is both clonally propagated and the world;s most important non-grain food crop, its genome is a valuable agricultural resource. The Potato Genome Sequencing Consortium sequenced two species: the heterozygous diploid S. tuberosum Group Tuberosum cultivar, RH89-039-16 (RH), and the doubled monoploid S. tuberosum Group Phureja clone DM1-3 516R44 (DM). The potato genome consists of 12 chromosomes, of which over 80% of the homozygous clone’s 844-megabase genome were assembled. Genome analysis revealed evidence of at least two genome duplication events and identified a number of asterid-specific genes. Comparison between the two clones identified frequent gene variations and mutations, which may cause inbreeding depression

The genomics revolution and development studies: Science, poverty and politics

The genomics revolution in biology has enabled technologies with unprecedented potential; genetic engineering is changing the terrain of development studies. Societies have reacted with indifference or appreciation to genetically engineered pharmaceuticals, beginning with insulin; yet for food and agriculture, a globally contentious politics and unprecedented policy dilemmas have arisen. Transgenic organisms raise questions of property, ethics and safety unimaginable a generation ago: what can be owned and with what responsibility? Much turns on science: how one conceptualizes evidence, knowledge, uncertainty and risk. Both opponents and proponents of frontier applications in biotechnology have a poverty story to tell, but with divergent implications. The balance in this global debate has perceptibly shifted; a new developmentalist consensus concludes that the world's poor may benefit from genetic engineering: the question is 'under what conditions'? This essay introduces a collection of scholarly treatments that begin with the needs of the poor�-�for income, nutrition, environmental integrity�-�and evaluate theory and evidence for contributions from transgenic crops. The new consensus assumes much about biosafety, bioproperty and biopolitics that is contrary to ground realities�-�the actual capacity of firms and states to monitor and control biotechnology�-�but raises new questions at the frontiers of development studies.